Synthesis of 4-substituted 2-azetidinones
نویسندگان
چکیده
منابع مشابه
Synthesis and biological activity of N-substituted-3-chloro-2-azetidinones.
2-Aminobenzothiazole-6-carboxylic acid (1), on condensation with chloroacetyl chloride yielded 2-(2-chloroacetylamino)benzothiazole-6-carboxylic acid (2), which on amination with hydrazine hydrate yielded in turn 2-(2-hydrazinoacetylamino)benzo-thiazole-6-carboxylic acid (3). Compound 3, on condensation with various aromatic aldehydes afforded a series of 2-{2-[N'-(arylidene)hydrazino]acetylami...
متن کاملAn expeditious iodine-catalyzed synthesis of 3-pyrrole-substituted 2-azetidinones.
2-Azetidinones and pyrroles are two highly important classes of molecules in organic and medicinal chemistry. A green and practical method for the synthesis of 3-pyrrole-substituted 2-azetidinones using catalytic amounts of molecular iodine under microwave irradiation has been developed. Following this method, a series of 3-pyrrole- substituted 2-azetidinones have been synthesized with a variet...
متن کاملSynthesis of Substituted 2-Pyridyl-4-phenylquinolines
Abstract: The acid-catalyzed condensation of o-aminobenzophenones with aromatic acetyl derivatives, in a basic methanol/tetrahydrofuran medium, has been used to prepare a series of substituted 2-pyridyl-4-phenylquinolines. Derivatives having two aza binding sites can act as asymmetric bidendate ligands to complex transition metals such as ruthenium, osmium or iridium. All the compounds were cha...
متن کاملSynthesis, Characterization and Study of Some N-Substituted Aryl-2- ({4-[(Substituted Aryl Carbamoyl) Methyl]-5-(Pyridin-4-yl)-4H-1, 2, 4-Triazol-3-yl} Sulfanyl) Acetamide
Pathogenic infections and inflammation are very common ailments humans suffer. Upsurge of resistant pathogens has impeded the antimicrobial drug development process in recent years and the search of new antimicrobial agents is clearly evident from the literature. In line with these developments the synthesis of N-substituted aryl-2-({4-[(substituted aryl carbamoyl) methyl]-5-(pyridin-4-yl)-4H-1...
متن کاملSynthesis of sulfazecin-type 2-azetidinones with a carbon substituent at the 4-position.
Sir: As reported in our previous paper,1) chemical modification of sulfazecin2) at the 3-position significantly enhanced its antibacterial activity; however, further improvement was desired especially in regard to the stability to some p-lactamases. We focused our attention on modifying the unexplored 4-position, and cis-1-(2,4dimethoxybenzyl)4methoxycarbonyl3 -phthalimido-2-azetidinone (1a) wa...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Tetrahedron Letters
سال: 1985
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)89144-3